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Wegovy® Pill
Once-daily morning tablet
*OASIS 4, 64-week study of adults with obesity using oral semaglutide 25mg alongside lifestyle changes. Individual results vary.
Wegovy® Pill information
Wegovy tablets contain semaglutide, a GLP-1 medication that works like a natural hormone in your body.
It targets the areas of your brain involved in hunger and appetite, helping to reduce food noise, lower cravings, and support long-term weight management.
This is the same active ingredient used in Wegovy injections, now available as a daily tablet.
Wegovy tablets and injections both contain semaglutide and work in the same way. The main differences are:
- How you take it: A daily tablet instead of a weekly injection. No needles needed.
- How often: Once a day (tablet) compared to once a week (injection).
- Storage: Wegovy pens need to be kept in the refrigerator, but tablets are stored at room temperature.
- Absorption: Because the tablet is absorbed through your digestive system, it needs to be taken on an empty stomach with specific timing. The injection is absorbed more predictably under the skin.
Some people prefer the simplicity of a daily tablet. Others prefer a weekly injection. Your clinician can help you decide what works best for you.
In a 64-week clinical trial, people taking oral Wegovy 25mg lost an average of 16.6% of their body weight when taken as directed*.
This means that someone who weighs 100kg could lose around 16.6kg on average in 64 weeks (just over 1 year). This is an example only. It is not a prediction of individual results.
Around 3 in 10 people in the trial lost 20% or more of their body weight.
*OASIS 4, 64-week study of adults with obesity using oral semaglutide 25mg alongside lifestyle changes. Individual results vary.
Wegovy tablets are taken once a day, every morning. To make sure the medication is absorbed properly, here’s how to take it:
- Take the tablet first thing when you wake up, on an empty stomach
- Swallow it whole with a small sip of plain water (no more than 120ml)
- Wait at least 30 minutes before eating, drinking anything else or taking other oral medications
- Do not split, crush or chew the tablet
The tablets can be stored at room temperature. There’s no need for refrigeration.
You will start on the lowest dose of 1.5mg, taken once a day. From there, your dose can increase every 30 days. The titration schedule is:
- Days 1-30: 1.5mg once daily
- Days 31-60: 4mg once daily
- Days 61-90: 9mg once daily
- Days 91 and onward: 25mg once daily (maintenance dose)
Your clinician will review your progress at each step and confirm the right dose for you. This gradual increase helps your body adjust and reduces the chance of side effects. Some people stay on a lower dose for longer, and that’s completely fine.
The full treatment effect is usually seen at the maintenance dose of 25mg. We also keep lifestyle front of mind. Finding your rhythm with food, movement and rest is just as important as finding the right dose.
The goal is simple: a balance that helps you feel well, manage side effects and make steady, sustainable progress.
We’re here to support you throughout your weight loss journey, offering tips to help you manage side effects and providing reassurance if you have any concerns.
Side effects tend to be more noticeable when you first start and when your dose increases. They usually improve as your body adjusts.
Very common side effects of oral Wegovy (semaglutide) include stomach upsets like nausea, vomiting, diarrhoea and constipation. You might also experience stomach pain, headaches and fatigue. Headaches and mild stomach problems, which are common, can usually be managed with over-the-counter remedies. To ease nausea, you can try stepping outside for fresh air, sipping cold drinks and eating smaller meals more often.
Less common side effects, affecting fewer than 1 in 100 people, may include a faster heart rate, low blood sugar (also known as hypoglycaemia), kidney stones and pancreatitis.
Rare side effects, occurring in fewer than 1 in 1,000 people, may involve a serious allergic reaction (also known as anaphylaxis) and angioedema, which is a type of swelling beneath the skin that can affect the face, lips, tongue or throat.
For rare, severe or worsening symptoms, we recommend you seek professional medical advice.
Keep an eye on how you feel and report any side effects that do not go away or get worse. Seek immediate medical attention if you experience difficulty breathing, swelling or severe stomach pain.
If you have any questions about side effects or how to manage them, we’re here to support you.
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Wegovy Pill facts
Treatment type
Prescription tablets (GLP-1)
Average weight loss
16.6% of your body weight in 64 weeks (1 year, 3 months)*
Available strengths
1.5mg – 25mg
Active ingredient
Semaglutide
*OASIS 4, 64-week study of adults with obesity using oral semaglutide 25mg alongside lifestyle changes. Individual results vary.
How it works
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Our qualified clinicians review your information and recommend treatment if it’s right for you.
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If prescribed, your treatment will arrive directly to you in discreet packaging.
Meet your team of experts
Dr. Bryony Henderson
Dr. Bryony Henderson is Medical Director for MedExpress UK, bringing extensive experience in clinical operations, governance and digital health. She has previously held roles dedicated to delivering safe, scalable care across well-known brands. She is a recognised clinical voice contributing to award-winning campaigns, publishing on health inequalities, and appearing across national media. Here, Bryony leads clinical governance and quality, supporting the delivery of safe, innovative and accessible healthcare.
Adedayo Titiloye
Adedayo Titiloye is Superintendent Pharmacist responsible for the safe and compliant delivery of pharmacy services across MedExpress. He brings experience across community pharmacy and regional operations, including leadership roles within one of the UK’s largest independent pharmacy groups. Here, Ade focuses on building high-performing teams, improving processes and ensuring pharmacy services deliver safe, effective care at scale.
Dr. Carla Rodrigues
Dr. Carla Rodrigues is Head of Medical Operations at MedExpress, having previously held leadership roles in primary care networks and across well-known healthcare organisations, and has led scientific society groups in the field of sexual medicine. She has also completed training with MIT, Harvard and INSEAD. At HeliosX, Carla leads medical operations in the UK, overseeing the delivery of safe care pathways and upholding high standards in prescribing and clinical governance.
Dr. Kavir Matharu
Dr. Kavir Matharu is a GP Lead at MedExpress, with 10 years’ experience across a range of healthcare settings. She is a practising GP with a background in complex healthcare consulting, having worked on high-level strategic and operational challenges within the health system. She was also selected for a leadership fellowship with the National Medical Director at NHS England. Kavir has a strong interest in healthcare leadership and system improvement, with a focus on high-quality, sustainable care.
Dr. Daryl Perera
Dr. Daryl Perera is a GP Lead at MedExpress, with experience across NHS primary care, urgent care and private practice. He has extensive experience in digital healthcare and clinical leadership, and oversees clinical governance and patient safety across our digital health services. His work spans urgent care and preventative medicine, with particular interests in men’s health, obesity management, and sport and exercise medicine. Daryl has worked across a range of NHS and private healthcare organisations and previously held a GP Director role.
Dr. Sophie Dix
Head of Medical Affairs
BSc (Hons), MSc, PhD
Dr. Sophie Dix is Head of Medical Affairs at MedExpress and a behavioural neuroscientist with over 25 years’ experience across the pharmaceutical industry, charity sector and health technology. Her work has focused on understanding how to manage and treat conditions affecting both mind and body, bringing together scientific insight with real-world care. Sophie is passionate about evidence and ensuring people have access to the right treatment at the right time.
Dr. Zoe Lees
Medical Writer
BSc (Hons), MSc, PhD
Dr. Zoe Lees is a Medical Writer at MedExpress, specialising in clear, evidence-based health communications. She completed her postgraduate research at the University of Glasgow, focusing on metabolic complications of pregnancy and the role of adipose tissue function. Zoe brings a strong scientific foundation to her work and is committed to delivering content that is both accurate and accessible, grounded in robust research.
Dr. Adam Abbs
Dr. Adam Abbs is Medical Director, International at MedExpress responsible for expanding the company into new markets. He has extensive experience in asynchronous and video consultations, technology-enabled remote examinations and home biomarker testing, with a particular interest in educating both patients and doctors. Adam is a published author and is licensed to practice medicine in the UK and across the EU, and is registered in Canada.
Liyya Patel
Liyya Patel is Deputy Chief Pharmacist at MedExpress UK, with over 10 years’ experience supporting the organisation’s growth and development. She is responsible for ensuring pharmacy services are safe, compliant and meet all regulatory standards, playing a key role in maintaining high-quality clinical care. Liyya previously worked in high-volume community pharmacy settings in Central London and is a qualified pharmacist and independent prescriber.
Dr. Olivia de Rougemont
Dr. Olivia de Rougemont is a GP Lead at MedExpress with over 12 years’ experience across the NHS and private sectors. She has extensive experience in digital and in-person care, with a particular interest in women’s health, preventative medicine, and delivering patient-centred support that feels clear and accessible. Olivia also leads and mentors GPs, and brings a global perspective shaped by her experience working across different healthcare systems.