UK registered pharmacy
UK licensed treatments
Trusted by over 1.5 million people
Nytol One-A-Night is a clinically proven sleep aid containing the active ingredient diphenhydramine hydrochloride. For those experiencing sleeping difficulties, Nytol One-A-Night acts as a sleep aid to help get a better night’s rest. It’s been shown to help people to fall asleep faster and to have a longer and deeper sleep.
Nytol One-A-Night can be taken to help relieve temporary sleeping difficulties, which is defined as any period of sleeplessness lasting up to two weeks. Sleeping difficulties may be experienced due to a range of underlying causes such as stress or jet lag.
Nytol One-A-Night contains a commonly used antihistamine called diphenhydramine hydrochloride. It works by blocking the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This helps reduce alertness and promote that first drowsy stage of sleep, helping you to then drift off into a restful, deeper sleep.
Take 1 tablet (50mg dose) with water 20 minutes before you go to bed.
Usually the effects of Nytol One-A-Night last between four and six hours after taking a dose. It is often reported that users feel some level of drowsiness the day after taking a dose; if this applies to you, avoid driving and operating heavy machinery.
Always read the patient information leaflet before starting treatment.
View patient information leaflet.Impressively quick service. Easy site to navigate and meds delivered by reliable Royal Mail, so well pleased. Thank you!
Great service, easy to navigate the questionnaire and far quicker service than waiting for the NHS services to approve and dispens...
Full information, quick delivery, follow up email. Professional would not purchase from anyone else.
Fantastic service and very fast delivery, very happy with this service.
Great prices and service. Delivered on time, every time. 10/10.
Very fast delivery, I am happy with the speed that I got to order what I needed and fast delivery, really needed to start taking t...
Such an easy way to get medication quickly. Superb service and quick delivery. I couldn’t even get through to my Drs so although t...
Extremely professional, competitively priced, quick delivery
Fantastic and quick response, no hassle trying to get a doctor appointment, thanks MedExpress.
I have used them many times & the procedure is very easy & the delivery very quick.
This is a brilliant service and so quick and efficient. I would have had to wait god knows how long for a GP appointment for this ...
Checked properly by a doctor before medication was prescribed and aftercare very good. Received yesterday kept up to date with the...
Very quick to dispatch and customer service excellent
Trustworthy, professional and speedy delivery service. I have used this pharmacy a few times and I would recommend!
Good prices, communication and speed of delivery.

No GP or pharmacy visits, just a quick online consultation.
No GP or pharmacy visits, just a quick online consultation. Share your symptoms and a brief medical history in around two minutes, all from the comfort of your home.

Select from our recommended UK-licensed medications.
Select from our recommended UK-licensed medications. You don’t need an existing prescription.

We’ll deliver direct to you.
We’ll deliver direct to you. We always use discreet logo-free packaging, so only you know what’s inside. After it arrives, get ongoing support from our team.
Usually delivered the next working day
Guaranteed next working day by 1pm
Guaranteed next working day by 9am
Usually collection next working day