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Nytol One-A-Night 50mg Tablets

Clinically proven night time sleep aid

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30,000+ service reviews
Nytol One-A-Night 50mg Tablets

  • check_circle_filledRelieves temporary sleeping difficulties
  • check_circle_filledShown to help people to fall asleep faster and to have a longer and deeper sleep
  • check_circle_filledTake 1 tablet 20 minutes before bed
  • check_circle_filled20 day supply of tablets

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  • Royal Mail 1st Class£2.90
    Usually delivered the next working day
  • Special Delivery 1pm£5.95
    Guaranteed next working day by 1pm
  • Special Delivery 9am£13.95
    Guaranteed next working day by 9am
  • Post Office Collection£3.95
    Usually collection next working day
  • Same Day (London)from £4.95
    Cost calculated at checkout

Nytol information

Nytol One-A-Night is a clinical proven sleep aid containing the active ingredient diphenhydramine hydrochloride. For those experiencing sleeping difficulties, Nytol One-A-Night acts as a sleep aid to help get a better night’s rest. It’s been shown to help people to fall asleep faster and to have a longer and deeper sleep.
Nytol One-A-Night can be taken to help relieve temporary sleeping difficulties, which is defined as any period of sleeplessness lasting up to two weeks. Sleeping difficulties may be experienced due to a range of underlying causes such as stress or jet lag.
Nytol One-A-Night contains a commonly used antihistamine called diphenhydramine hydrochloride. It works by blocking the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This helps reduce alertness and promote that first drowsy stage of sleep, helping you to then drift off into a restful, deeper sleep.
Take 1 tablet (50mg dose) with water 20 minutes before you go to bed.
Usually the effects of Nytol One-A-Night last between four and six hours after taking a dose. It is often reported that users feel some level of drowsiness the day after taking a dose; if this applies to you, avoid driving and operating heavy machinery.
Always read the patient information leaflet before starting treatment.View patient information leaflet
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Backed by our experienced UK-based medical team

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Dr Catriona Maybury

Medical Director | MBChB, MRCP, PhD

GMC: 6130975

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Declan Lismore

Superintendent Pharmacist | MPharm, MRPharmS, MPSI, PGDip

GPhC: 2073498

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Dr Paul Davis

UK Medical Operations Lead | BSc MB BS DCH MRCGP

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Dr Safia Hussain

MBBS, BSc, MRCGP, DRCOG, PGDip Clinical Dermatology

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Authored by Dr Clare Morrison. Last reviewed 01 February 2024 by Liyya Patel and Siobhan Titre.