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*The evidence comes from STEP UP, a 72-week clinical trial in adults with a BMI of 27 or above using Wegovy (semaglutide 7.2mg). Studies in people with lower BMIs are limited, so results and safety are less certain. Weight loss cannot be guaranteed.
**SELECT study; Wegovy shown to cut the risk of major cardiovascular events by 20% in adults with obesity and heart disease. Individual results vary.

Wegovy (semaglutide) is a once-weekly weight loss injection. It's suitable for people with a BMI over 30. It’s also available for people with a BMI over 27 who have additional weight-related health concerns, like high blood pressure, type 2 diabetes, heart disease, and raised cholesterol.
Wegovy mimics a natural hormone in the gut that helps to control your appetite and make you feel fuller.
The Wegovy injection is a pre-filled pen. It should be used once a week, on the same day each week. This will help ensure that the medicine works as effectively as possible. The pen is simple to use, and the needles are very small, so it’s relatively pain-free and easy to get used to.
Wegovy can be injected in the abdomen, thigh or back of the upper arm at any time during the day, with or without food.
You’ll receive clear instructions with your first order, and the Wegovy website has lots of useful information too.
Wegovy is suitable for people with a BMI of ≥ 30, or for people with a BMI ≥ 27 who have a weight-related health concern such as high blood pressure, prediabetes or high cholesterol.
Wegovy is also suitable for people with a BMI of ≥ 27 and established heart disease, to reduce the risk of major adverse cardiovascular events such as a heart attack, stroke, or death from heart disease.
If you have type 2 diabetes and a BMI less than 27, we can’t prescribe you Wegovy for weight loss.
To find the right Wegovy dose, you’ll begin with a low dose (0.25mg once a week) to help your body adjust comfortably. From there, your dose may increase gradually over time, but there’s no single “right” pace or target.
Some people find they’re reaching their goals and tolerating treatment well at a lower dose, while others may benefit from stepping up. What matters most is finding the dose that works best for you, balancing comfort, results, and your personal health goals.
Our Clinical team will review your progress to make sure Wegovy is delivering meaningful results for you before continuing treatment. You can learn more about each dose here.
In 72 weeks, people taking Wegovy injection 7.2mg in a clinical study lost an average of 20.7% of their body weight. This means that someone who weighs 100kg may lose 20.7kg on average in 72 weeks (1 year, 5 months). This is an example only. It’s not a prediction of individual results.*
*STEP UP, 72-week study of adults with obesity using Wegovy (semaglutide 7.2mg). Individual results vary.
Wegovy is available online at MedExpress. To find out if you're suitable for treatment, start a quick consultation here.
The cost of Wegovy is based on your dose strength. You can find detailed information here.
When you order the Wegovy injectable pen for the first time, you’ll receive the lowest dose (0.25mg). Each pen contains 4 doses, which is enough for your first 28 days of treatment.
Each first order box of Wegovy comes with:To get started, complete the consultation for an injectable weight loss pen and select the starter pack. With each new order, you’ll receive your next pen and needles, delivered without cold packaging. Once your treatment arrives, store your treatment in the fridge and refer to storage guidance included with your parcel if you have any questions.
Wegovy is available in the following doses:
However, please note that your actual titration schedule may vary based on your individual circumstances, including how much weight you've lost and your tolerance of side effects.
You’ll begin on a low starting dose, taken once a week. From there, you can move up gradually or stay where you feel comfortable, and your clinician will review your choice and confirm it’s safe and sustainable for you.
Over time, some people choose to reduce their dose to maintain results or manage side effects.
You’ll receive a sharps bin with your first order. This is a special waste bin that’s used to store sharps material, like needles, until it can be safely disposed of.
After every use, dispose of the needle into the sharps bin. After the 4 doses, and once the needle has been removed, the pen can be disposed of in your household waste or the sharps bin. When full, your sharps bin may be collected for disposal by your local council or exchanged for a new one at a local pharmacy.
Wegovy is a licensed, prescription-only medicine, and it's safe for most eligible adults when taken under clinical supervision.
The most common side effects of Wegovy are digestive: nausea, diarrhoea, constipation, indigestion, and vomiting. These are usually mild, and tend to settle as your body adjusts to treatment.
Rare but serious risks include pancreatitis and gallbladder problems. Signs to watch for include sudden severe stomach pain, persistent vomiting, or pain under the right rib cage that spreads to your back or shoulder. Seek medical help straight away if you notice these.
You can find detailed side effect information in your patient information leaflet, or on our blog.
Always read the patient information leaflet before starting treatment.
Using Wegovy for about 4 weeks now and not only the product itself is fantastic, but the service from MedExpress is fantastic from consultation, ordering, delivery, re-ordering reminders. Also great to see the links between MedExpress and my own GP here in Northern Ireland. Would highly recommend MedExpress.
Great pharmacy quick delivery. Have been using the weight loss injections for about 3 months and have lost over 5kg with hardly any exercise as I'm disabled so can't really exercise. Only side effect I'm feeling is constipation. Great great product.
My medication comes quickly, if I have any query questions, I can just email them and then they get back to me. I'm pleased to say that the Wegovy injections that I have are now starting to work, so I'm really happy 😁
I have tried all diets this one actually works by making you feel full. I would recommend it to anyone to shed some pounds.
Prescription injection (GLP-1)
20.7% of your body weight in 72 weeks (1 year, 5 months)*
0.25mg – 7.2mg
Semaglutide
*STEP UP, 72-week study of adults with obesity using Wegovy (semaglutide 7.2mg). Individual results vary.

Complete a short online consultation. No waiting rooms or queues.

Our qualified clinicians review your information and recommend treatment if it’s right for you.

If prescribed, your treatment will arrive directly to you in discreet packaging.
Wegovy can be injected in the back of the upper arm, thigh or abdomen on a weekly basis. It uses a very small, fine needle for a near-painless injection just below the surface of the skin. The Wegovy pen comes ready to use, with a button that delivers the right amount of medication for your treatment stage. Once you’ve had the injection, remove the needle and dispose of it in a sharps bin.
Each Wegovy pen contains 4 doses and will therefore last 4 weeks assuming that you take your medication as directed (once weekly).
No. Each pen contains 4 doses, and you will use the same pen with a different needle each week. Once you've completed all your doses, the pen should be disposed of.
You can contact our support team at hello@medexpress.co.uk.
Wegovy is one of the most effective weight loss treatments available.
In 72 weeks, people taking Wegovy 7.2mg in a clinical study lost an average of 20.7% of their body weight when the medication was taken as directed. This means that someone who weighs 100kg may lose 20.7kg on average in 72 weeks (1 year, 5 months). This is an example only. It's not a prediction of individual results.*
Everyone responds differently, and higher doses can increase the risk of side effects. Your clinician will assess whether this dose is suitable for you.
*STEP UP, 72-week study of adults with obesity using Wegovy (semaglutide 7.2mg). Individual results vary.
We need to assess your weight once you’ve been taking Wegovy for around 6 months. If you’ve lost 5% of your initial weight at that assessment, you're likely to be able to continue using it for up to 2 years with clinical guidance.
Yes, around 6 months into treatment we'll check in with you to find out how your weight loss is going.
If you have any queries or concerns, you can contact our support team at any time.
If you experience symptoms such as persistent nausea, vomiting and diarrhoea with your current Wegovy dose, speak to our customer care team for advice. We may recommend delaying your next dose increase for a few more weeks to see if that helps improve your tolerance. We can also give you tips to help manage any symptoms and get maximum benefit from the medication. It’s important to not increase your Wegovy dose until your body is ready, so make sure you contact MedExpress if you have persistent side effects.
If you are concerned by your symptoms, review your patient information leaflet or seek medical attention.
Yes, Wegovy is licensed for weight loss in the UK.
Always carry your Wegovy pen in your hand luggage. Never place it in your checked baggage, as the aircraft hold can expose it to freezing temperatures that could damage the medication. Use a travel cooler to help keep your Wegovy pen cold, especially if you’re travelling for extended periods in warm climates.
Unopened Wegovy pens should be stored in a refrigerator between 2°C and 8°C. If that’s not possible, the pen can be kept at room temperature (up to 30°C) for up to 28 days. It’s important not to use any pen that has been exposed to temperatures outside this range.
To pass through airport security smoothly, make sure you carry your prescription with your name on it, along with the original box your medication came in. Carry your passport as your primary ID, and consider having extra proof of address (such as a utility bill) on hand in case further verification is requested.
Airline policies on travelling with medication can vary, so it’s best to contact your specific airline ahead of time to check what’s required for carrying medication on board.
If you miss a dose of Wegovy, it should be administered as soon as possible, as long as it's within 5 days after the missed dose. If more than 5 days have passed, the missed dose should be skipped, and the next dose should be taken on the regularly scheduled day. From there, you can continue the once-weekly dosing schedule.
Yes. A major clinical trial found that Wegovy reduces the risk of heart attack, stroke and death from heart disease by up to 20% in people living with obesity or who are overweight and have pre-existing heart disease, even if they don’t have diabetes.*
*Michael Lincoff et al. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes. The New England Journal of Medicine [Internet]. 2023 Nov 11 [cited 2026 Aug 28];389(24). Available from: https://www.nejm.org/doi/10.1056/NEJMoa2307563
Wegovy can support heart health by:
*Clinical Review [Internet]. Nih.gov. Canadian Agency for Drugs and Technologies in Health; 2025 [cited 2026 Aug 28]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK619926/
People with overweight or obesity that have pre-existing heart disease.
For example, if you are living with obesity or are overweight (BMI ≥ 27), and have previously had a heart attack, a stroke or poor blood flow to the limbs, you may be eligible for treatment.
Wegovy should not be used during pregnancy.
If you're planning to become pregnant, stop using Wegovy at least 2 months in advance.
If you're sexually active and able to become pregnant, you should use contraception while taking Wegovy. You can use oral contraceptive pills, non-oral methods such as the implant or IUD, or barrier methods like condoms.
However, if you experience sickness or diarrhoea as a side effect of your treatment, your oral contraceptive may not be effective at preventing pregnancy, so an additional barrier method such as condoms should be used.
Wegovy does not impact the effectiveness of the oral contraceptive pill. However, if you experience sickness or diarrhoea as a side effect of your treatment, your oral contraceptive may not be effective at preventing pregnancy, so an additional barrier method such as condoms should be used.
If you're planning to become pregnant, it's recommended that you wait at least 2 months after your last dose of Wegovy to start trying.
No, do not use Wegovy while breastfeeding. It's not yet known whether it could affect a breast-fed baby.

Dr. Adam Abbs is Medical Director at MedExpress. He has extensive experience in asynchronous and video consultations, technology-enabled remote examinations and home biomarker testing, with a particular interest in educating both patients and doctors. Adam is a published author and is licensed to practice medicine in the UK and across the EU. He’s also registered in Canada.

Dr. Carla Rodrigues is Head of Medical Operations at MedExpress, having previously held leadership roles in primary care networks and across well-known healthcare organisations. She’s led scientific society groups in the field of sexual medicine, and has also completed training with MIT, Harvard and INSEAD. Here, Carla leads medical operations in the UK, overseeing the delivery of safe care pathways and upholding high standards in prescribing and clinical governance.

Dr. Kavir Matharu is GP Lead at MedExpress, with 10 years’ experience across a range of healthcare settings. She is a practising GP with a background in complex healthcare consulting, having worked on high-level strategic and operational challenges within the health system. She was also selected for a leadership fellowship with the National Medical Director at NHS England. Kavir has a strong interest in healthcare leadership and system improvement, with a focus on high-quality, sustainable care.

Dr. Daryl Perera is GP Lead at MedExpress, with experience across NHS primary care, urgent care and private practice. He has extensive experience in digital healthcare and clinical leadership, and oversees clinical governance and patient safety across our digital health services. His work spans urgent care and preventative medicine, with particular interests in men’s health, obesity management, and sport and exercise medicine. Daryl has worked across a range of NHS and private healthcare organisations and previously held a GP Director role.

Head of Medical Affairs
BSc (Hons), MSc, PhD
Dr. Sophie Dix is Head of Medical Affairs at MedExpress, and a behavioural neuroscientist with over 25 years’ experience across the pharmaceutical industry, charity sector and health technology. Her work has focused on understanding how to manage and treat conditions affecting both mind and body, bringing together scientific insight with real-world care. Sophie is passionate about evidence and ensuring people have access to the right treatment at the right time.

Medical Writer
BSc (Hons), MSc, PhD
Dr. Zoe Lees is a Medical Writer at MedExpress, specialising in clear, evidence-based health communications. She completed her postgraduate research at the University of Glasgow, focusing on metabolic complications of pregnancy and the role of adipose tissue function. Zoe brings a strong scientific foundation to her work and is committed to delivering content that is both accurate and accessible, grounded in robust research.

Liyya Patel is Deputy Chief Pharmacist at MedExpress UK, with over 13 years’ experience supporting the organisation’s growth and development. She is responsible for ensuring pharmacy services are safe, compliant and meet all regulatory standards, playing a key role in maintaining high-quality clinical care.

Dr. Olivia de Rougemont is GP Lead at MedExpress, with over 14 years’ experience across the NHS and private sectors. She has extensive experience in digital and in-person care, with a particular interest in women’s health, preventative medicine, and delivering patient-centred support that feels clear and accessible. Olivia also leads and mentors GPs, and brings a global perspective shaped by her experience working across different healthcare systems.

Dr. Karuna is GP Lead at MedExpress. She brings a broad portfolio of experience in NHS primary care, including general practice, NHS 111, and urgent care services. She has extensive expertise in digital healthcare, providing remote consultations to both NHS and private patients, and previously held a senior leadership role in a large scale digital-first healthcare platform.
Treatment begins with a low starting dose, which may be gradually increased every four weeks based on your progress.
| Dosage | Price |
|---|---|
| 0.25mg | £99.99 |
| 0.5mg | £119.99 |
| 1.0mg | £149.99 |
| 1.7mg | £179.99 |
| 2.4mg | £199.99 |
| 7.2mg | £279.99 |