Choosing Generic vs Branded Spedra


Generic medicines contain the same active ingredient and are equally effective and equivalent as the branded products but are available at a lower price. Generic manufacturers have to demonstrate that they are medically identical to the branded product before they can be sold - i.e. they offer the same quality, strength, stability and effectiveness.


Erectile Dysfunction Treatment

Lower strength recommended for patients experiencing side effects
Standard strength recommended for new patients
Higher strength recommended only after trying 100mg without success
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Compare Prices to Competitors

Spedra 50mg
MedExpress Health Express
4 tablets
£ 24.99
8 tablets
£ 49.99 £98.95
12 tablets
£ 64.99 £147.95
16 tablets
£ 89.99 £194.95
24 tablets
£ 129.99 -
32 tablets
£ 169.99 £354.95
UK Price Comparison. Comparison Date 19/04/2016 Source:
Spedra 100mg
MedExpress Lloyds Pharmacy Health Express Superdrug
4 tablets
£ 28.99
£34.00 £51.95 £49.00
8 tablets
£ 54.99 £61.00 £102.95 £89.00
12 tablets
£ 79.99 - £153.95 -
16 tablets
£ 99.99 £105.00 £202.95 -
24 tablets
£ 149.99 - - -
32 tablets
£ 199.99 - £370.95 -
UK Price Comparison. Comparison Date 19/04/2016 Source:
Spedra 200mg
MedExpress Lloyds Pharmacy Health Express Superdrug
4 tablets
£ 36.99
£44.00 £53.95 £74.00
8 tablets
£ 69.99 £76.00 £106.95 £139.00
12 tablets
£ 104.99 - £159.95 -
16 tablets
£ 134.99 £141.00 £210.95 -
24 tablets
£ 199.99 - - -
32 tablets
£ 269.99 - £386.95 -
UK Price Comparison. Comparison Date 19/04/2016 Source:

Spedra Info

What is Spedra?

Spedra contains the active ingredient avanafil and is used to effectively treat erectile dysfunction. It has a quick onset of action in comparison to other treatment options available and many men find that it works effectively just 15 minutes after taking the pill. It is one of the most recent drugs to be released for use in the treatment of erectile dysfunction.

What is the difference between Viagra and Spedra?

Viagra contains the active ingredient sildenafil whereas Spedra contains avanafil. They are two completely different drugs, although they have a similar effect on the body. They both work by increasing blood flow to the penis for an erection to occur, are equally effective and last a comparable amount of time. However, Spedra is absorbed more quickly and hence begins to work faster.

What is erectile dysfunction?

Erectile dysfunction involves difficulty for men in getting and keeping an erection adequate for sexual activities. It is also sometimes known as impotence.

Normally when you are sexually aroused your brain receives sensory messages - what you feel and see - and reacts by changing hormone levels and relaxing certain muscles around blood vessels in the penis. This allows more blood to flow through the enlarged vessels to allow an erection to occur.

The most common cause of erectile dysfunction is cardiovascular disease because the blood vessels are particularly important in the final step of getting an erection. However, as it is such a complex process, there are many possible causes. For example, psychological causes like stress and anxiety can affect the brain's response to arousal and cause erectile problems.

It is important to seek treatment early as sexual performance problems can cause further anxiety and set a pattern of failure. Treatment can help to remove the physical barriers and allow you to address the issues with your partner or therapist in the meantime.

How does Spedra work?

The active ingredient in Spedra, avanafil, is a type of drug called a PDE-5 (phosphodiesterase type 5) inhibitor, like the majority of drugs available for the treatment of erectile dysfunction.

Spedra stops a particular enzyme in the body from working properly, preventing it from keeping the muscles surrounding the blood vessels in the penis tight. As a result, the blood vessels can widen and allow more blood to pass through and an erection to occur.

Regardless of the cause of erectile dysfunction, Spedra can work effectively as it affects the very last step of the erection process. However, as it works specifically on the physical side of things, it won't help to increase sexual desire.

How do you take Spedra?

You should take 1 tablet whole with a glass of water 30 minutes to 1 hour before planning to have sex. Whilst some men find it is effective within 15 minutes, waiting this time will allow your body more time to experience the effects of the drug.

You can take Spedra with or without food as desired, although if you take it with or soon after a large meal it may take slightly longer to work.

What dose should you take?

Spedra comes in three doses: 50, 100 and 200 mg. For people beginning treatment with Spedra, it is recommended to begin with the standard dose of 100mg. If this is effective for you and you do not experience any other problems, continue with this dose.

However, if you experience side effects that bother you, you may prefer to try decreasing the dose to 50 mg. This helps many men to decrease unwanted effects whilst maintaining the desired effect.

On the other hand, some men find that the standard dose is not powerful enough to give the results they desire. If after trying the standard dose on 4 separate occasions and you are not happy with the outcome, you may try increasing the dose to 200 mg. If this is still not effective and you have tried on 8 separate occasions, you should see your doctor for information on other treatment options for you.

Are there side effects?

All medications have an effect on the body and can also produce unwanted side effects. The most common side effects for Spedra are:

  • Headache
  • Facial flushing
  • Back pain
  • Nausea
  • Indigestion
  • Blurry vision
  • Nasal congestion

If you notice these side effects and they bother you, you may be able to eliminate them by trying the lower dose of Spedra. If you still experience these effects, you should talk to your doctor about other treatment options.

Side Effects

Common Side Effects

  • pain in your back/muscles/head
  • migraines
  • getting flushed/going red
  • indigestion
  • feeling and or being sick
  • getting a blocked or runny nose
  • vision disturbances


Alternatives to Spedra


For many men suffering from erectile dysfunction the primary cause may be related to psychological issues and not physical ones.

In these cases, counselling can prove to be a very effective form of treatment. Talking with a mental health professional will help to address issues of stress, anxiety or depression, which can all contribute to erectile dysfunction. For further information contact your GP.

Other ED Medications

We offer a range of ED medications. Visit our full range here.

Information Leaflet

Patient Information Leaflet

Always read the patient information leaflet before commencing treatment. View patient information leaflet.

Authored 22 April 2014 by Dr Clare Morrison Reviewed 31 January 2019 by Liyya Patel, Siobhan Titre Last updated 11 November 2018

Recent Spedra Reviews

4.5 / 5

Based on 51 independent customer reviews taken by Feefo (see all MedExpress Reviews).

"A quick and complete service."
By John (Southampton) on 23 July 2019


I received exactly what I asked for.


The web site was easy to negotiate and the products and options clearly defined. Items were plainly packed and quickly delivered.

By Ronald on 09 November 2017


Very good. Got what I wanted


Very helpful and courteous,

"Just what the doctor ordered"
By Kenneth (Liverpool) on 25 February 2017


Does exactly what it says on the tin lol


Delivered on time and only at the. P.O one mile from home. Great

"top service"
By Andy on 14 February 2017


will try another product fom your range


very fast service as promised .think I will try another product from you

"Excellent service by MedExpress Online Pharmacy"
By Richard on 11 January 2017


It worked great will be trying the 200mg on my next purchase


Spedra 100mg excellent sevice and delivery

Read More Spedra Reviews

Discreet Service

Plain packaging

Option to collect from
your local Post Office™

local branches

How our service works

It’s quick, easy, and safe to order from MedExpress — your fully regulated, London based online pharmacy.

Free online

Start a free 2 minutes online consultation with simple questions about your health.


Our UK medical team will then recommend a treatment and issue a free prescription.


Your treatment will be sent direct from our London pharmacy in discreet packaging.

Watch our video to find out more

Our qualified team

All our doctors and pharmacists are based in the UK and are registered with the General Medical Council and General Pharmaceutical Council.

Dr Clare Morrison

General Practitioner (Prescriber)
GMC: 3441561

Dr Heather Currie

General Practitioner (Prescriber)
GMC: 2613354

Dr Syed Arfeen

Primary Care Physician
GMC: 6031426

Delivery Information

We’ve got a range of delivery options that suit you. All medication is sent using non-branded, discreet packaging.

Delivery service Price Details
Signed For 1st Class £2.90

Usually Next Working Day (including Saturdays). May take up to 3 working days.

Orders placed before 4pm on weekdays will be dispatched the same day.

Special Delivery 1pm Guaranteed £5.95

Guaranteed Delivery Before 1pm Next Working Day (including Saturdays to residential addresses).

Orders placed before 4pm on weekdays will be dispatched the same day.

Special Delivery 9am Guaranteed £13.95

Guaranteed Delivery Before 9am Next Working Day (including Saturdays to residential addresses).

Orders placed before 4pm on weekdays will be dispatched the same day.

Post Office Collection £3.95

Collect from your local Post Office.

Usually Next Working Day (including Saturdays). May take up to 3 working days.

Same Day Courier (London Only) £4.95-£19.95 (depends on distance)

Same day delivery (available Monday - Friday on orders placed before 4pm). Signature required on delivery.

Orders over the weekend will be delivered on Monday.

Delivery to remote Scottish Highlands & British Isles may not be guaranteed and may take longer than 1 day (more info) .
Delivery service Price Details
Royal Mail International Signed For £4.95

Express delivery within selected EU zone countries. Western Europe within 3 working days. Eastern Europe 5 working days.

Orders placed before 4pm on weekdays will be dispatched the same day.

This medicine is available for delivery to: Cyprus, Denmark, Finland, Germany, Greece, Malta, Sweden, United Kingdom

*We ship to EU countries where sales of prescription medications online are permitted. Find out more.

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