Choosing Generic Vs Branded Differin


Generic medicines contain the same active ingredient and are equally effective and medically equivalent as the branded products but are available at a lower price. Generic manufacturers have to demonstrate that they are medically identical to the branded product - i.e. they offer the same quality, strength, stability and effectiveness.

Generic medicines are required meet the same standards of safety, quality and efficacy as the branded medication. To receive market approval from the European Medicines Agency and MHRA, a generic medicine must be 'bioequivalent' to the originator product.

Differin (Adapalene) 0.1%

Prescription Acne Treatment

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Our Prices

Differin Cream 45

  • 1 Tube - £33.00
  • 2 Tubes - £62.00
  • 3 Tubes - £85.00

Differin Gel 45

  • 1 x 45g - £33.00
  • 2 x 45g - £62.00
  • 3 x 45g - £85.00

What is Differin?

What is Differin?

Differin is a gel that is used in the treatment of moderate to severe acne. It contains the active ingredients adapalene.

Adapalene belongs to a group of medicines called retinoids (which includes tretinoin) and helps to reduce inflammation and black and white head formation on the outer layer of the skin. Adapalene is an advanced third generation retinoid which exhibits many of the same effects as previous generation medicines like tretinoin but is often tolerated better.

How do I apply Differin?

Apply a thin layer of gel evenly over the acne affected areas only once daily at bedtime. Do not apply near or to the eyes, lips, nostrils or other sensitive areas. The gel should be applied to clean, dry skin and take care to wash your hands thoroughly before and after use.

Do not apply to broken skin.

How do I buy Differin?

Differin is a prescription only medicine and cannot be bought over the counter. If you are interested in this medicine, why not fill out our consultation questionnaire? This will be reviewed by one of our expert prescribers who will advise if this medicine is suitable and safe for you.

How long does it take to see results?

As with all medicines applied to the skin in the treatment of acne, you may not see results for up to eight weeks. It is important to be consistent in your application of this gel in order for it to work properly.

Is there anybody who cannot use Differin?

Differin is not suitable for those with a hypersensitivity to any of the ingredients. Do not use in pregnancy. Avoid sunlight and UV lamps while using this medicine. Do not use other acne products containing retinoids or benzoyl peroxide while using this medicine or products that are irritating, drying or exfoliating to the skin.

Side Effects

Side Effects

Some people can experience stinging sensation, dryness, scaling and burning sensitivity when they first use this medicine. This presents worst during the first week of use and then tends to settle.

Information Leaflet

Patient Information Leaflet

Always read the patient information leaflet before commencing treatment.

Authored 02 April 2020 by Dr Clare Morrison, Reviewed 02 April 2020 by Liyya Patel, Siobhan Titre Last updated 02 April 2020

Recent Differin Reviews

4.9 / 5

Based on 20 independent customer reviews taken by Feefo (see all Reviews).

"Totally reliable"
By IAN on 14 November 2020


Does exactly what it’s supposed to!


Really fast delivery. Easy process. Nice communication. Highly recommended

"Great service and very good price. Would definitely recommend."
By Juliana on 08 September 2020


Great product. Definitely works on my spots. I could see improvement in few days after applying it just once per day.


Easy to navigate website. Reasonably priced products and fast delivery. Excellent service overall. Would definitely recommend to a friend.

"Great service, great products"
By Hannah (Hook) on 05 June 2020


My purchase arrived quickly and was excellent quality. Will definitely purchase from MedExpress in the future


Very fast delivery, easy to use website. Excellent product. Will definitely use service in the future.

"Would definitely use again"
By Judith (Birmingham) on 23 June 2019


Does exactly what it’s supposed to do


Very pleased with service

"reliable service"
By Doug on 21 March 2019


arrived as desrcibed good product


good service

Read More Differin Reviews

Discreet Service

Plain packaging

Option to collect from
your local Post Office™

local branches

How our service works

It’s quick, easy, and safe to order from MedExpress — your fully regulated, London, United Kingdom based online pharmacy.

Free online

Start a free 2 minutes online consultation with simple questions about your health.


Our UK medical team will then recommend a treatment and issue a free prescription.


Your treatment will be sent direct from our London pharmacy in discreet packaging.

Watch our video to find out more

Our qualified team

All our doctors and pharmacists are based in the UK and are registered with the General Medical Council and General Pharmaceutical Council.

Dr Clare Morrison

General Practitioner (Prescriber)
GMC: 3441561

Avnish Patel

GPhC: 2079950

Rukhsana Deshmukh

Superintendent Pharmacist
GPhC: 2070765