See whether Wegovy or Mounjaro offers better value for you£25.00 per dose
In anonymised MedExpress data, people prescribed Mounjaro lost an average of around 20%* of their body weight after 12 months. Individual results vary.
* In clinical studies, adults with obesity using Mounjaro (tirzepatide 15mg) alongside lifestyle changes achieved average weight loss of around 21% (and up to 25%) after 72 weeks.
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105kg
After 12 months
Weight loss
Total cost
Cost per kg
Weight loss
Total cost
Cost per kg
 Wegovy® (semaglutide) |  Mounjaro® (tirzepatide) |
|---|---|
Price range £99.99–£199.99 | Price range £179.99–£309.99 |
Average weight loss (in clinical studies)* Up to 20% of body weight | Average weight loss (in clinical studies)* Up to 25% of body weight |
Treatment schedule Weekly injection | Treatment schedule Weekly injection |
Dose adjustments Gradual, guided by your clinician | Dose adjustments Gradual, guided by your clinician |
Suitable for oral contraception? Yes | Suitable for oral contraception? No |
Injection site reactions (in studies)** Reported in 5% of participants | Injection site reactions (in studies)** Reported in 4.4% of participants |
Heart health indication*** Approved to reduce the risk of heart disease in adults with obesity or overweight and existing heart conditions | Heart health indication*** Not currently licensed for this use |
* Effectiveness: In studies, the highest dose of Mounjaro (tirzepatide) plus healthy lifestyle changes led to an average weight loss of up to 20.9% in 36 weeks and 25.3% in 88 weeks. Wegovy (semaglutide) users lost around 15% of their weight in 68 weeks with diet and exercise changes.
** In SURMOUNT-1, the pooled average for injection site reactions from 2,539 participants was 4.4% with Mounjaro. For Wegovy, this was 5.0% in the STEP-1 clinical trial of 1,961 participants.
*** Heart health: Clinical trials show Wegovy can reduce the risk of heart attack, stroke and death from heart disease by up to 20% in people with obesity or who are overweight and have existing heart disease, even if they don’t have diabetes.
Management of my appetite was the biggest challenge, so the medication [Wegovy] has really just been game-changing. I've been trying to lose weight for 14 years. As soon as I knew about this medication from my research, I ordered it the same night I found out it was available.
I had tried every diet under the sun. I finally plucked up the courage… and it has changed my life. I am happier, more confident, full of energy and able to run around after my children for longer. [It] has drastically improved my physical, emotional and mental health.
I was starting to get a pain in my knee which seems to have decreased a lot since losing the weight. I don't get any more back pain. It's made me a lot more confident within myself. I actually want to go out and do things. I want to go clothes shopping. I want to enjoy things with my kids.
I can do more. I feel more energetic. I can play more with my kids, whereas before I was restricted. It's mostly the breathlessness, the being slow, being out of breath, feeling heavy, not being able to put my clothes on properly because they were too tight. It's been a brilliant experience with MedExpress.
I used to hide away in oversized clothes, just trying to feel comfortable—but I had no confidence. Now, I'm fitting back into clothes I haven't worn in years, and I actually enjoy getting dressed in the morning. I feel happier, more confident, and like I'm finally showing up as myself.
It's making me more happy about myself. I'm feeling more confident. I'm not hiding. If my friend invites me for a coffee, I won't say no anymore. I'm dressing-up! I'm taking care of myself now. I feel more happy every day. I'm more talkative. I'm going to more family events.
Switching medications is a normal and common occurrence — it’s something medical professionals recommend regularly for conditions like high blood pressure or high cholesterol, whether it’s to reduce side effects or lower costs.
However, you may not need to switch from Mounjaro, but instead explore a lower dose. We’ll work with you to find the solution that’s right for your needs, budget and goals.
Both Wegovy (semaglutide 7.2mg) and Mounjaro (tirzepatide 15mg) are highly effective for long-term weight loss, but they work slightly differently and may affect people differently.
In clinical trials, people taking Wegovy 7.2mg lost an average of around 19% of their body weight in 72 weeks*, while those taking Mounjaro (tirzepatide 15mg) lost around 21%**.
The best choice depends on personal preference, how you tolerate each medication, your weight-loss progress, and cost.
Because these medicines work differently in the body, individual responses vary. The most effective treatment in the long term is often the one you can tolerate well, stay on consistently, and use safely under medical guidance. Your prescriber will review your side effects and progress, and if you are coping well and your weight loss has stalled on 2.4mg, they may prescribe you the 7.2mg dose.
*Based on a 72-week study of adults with obesity using Wegovy (semaglutide 7.2mg).
**Based on a 72-week study of adults with obesity using Mounjaro (tirzepatide 15mg).
Wegovy and Mounjaro work in similar ways, so some people experience similar side effects. The most common are digestive effects such as nausea, vomiting, diarrhoea, constipation and stomach discomfort.
Side effects are usually mild to moderate and often improve as your body adjusts to treatment.
If you tolerated Mounjaro well, you may have a similar experience on Wegovy. However, everyone responds differently depending on the dose and individual factors. Your clinician will review your health and treatment history before switching, to help you move safely and comfortably.
A note about the higher Wegovy 7.2mg doseThe highest dose of Wegovy (7.2mg) can sometimes cause a temporary side effect called dysesthesia. This can feel like tingling, pins and needles, buzzing, or a mild burning sensation on the skin. It is not nerve damage and usually improves over time, even while continuing treatment.
In clinical studies:
Most side effects were mild to moderate and settled over time. Your care team will monitor your response closely and can adjust your dose if needed to help manage side effects and keep your treatment safe and comfortable.
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