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Malarone & Generic Malarone information
Side effects with Malarone are less common and severe than other anti-malaria drugs.
Side effects may include: rashes, abdominal pain, headaches, anorexia, nausea, diarrhoea, dizziness, change in sleep pattern, coughing and mouth ulcers.
It contains two medicines, atovaquone and proguanil hydrochloride, which both work in different ways to stop infection with the malaria parasite (Plasmodium falciparum). Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite into the bloodstream. Malarone prevents malaria by killing this parasite. For people who are already infected with malaria, Malarone also kills these parasites.
Malaria is a serious tropical disease spread by mosquitoes. If malaria is not diagnosed and treated promptly, it can be fatal.
Malaria is not a problem in the UK. More information about the risk of malaria in specific countries can be found on the Travel Health Pro website.
Find out if there is a malaria risk in the area you are visiting. To check whether you need to take preventative malaria treatment for the countries you are visiting, see the Travel Health Pro website, operated by the National Travel Health Network and Centre (NaTHNaC). Aspects of travel may increase the risk e.g. rural travel, rainy season or unscreened accommodation.
Use clothing to protect the skin, particularly between dusk and dawn when mosquitoes feed. Use DEET-based insect repellent on exposed areas of skin. Sleep under a mosquito net that is impregnated with insecticide. Use air conditioning (if available) and plug in vapourisers to protect your room.
The antimalarial tablets recommended for you will depend not only on effectiveness but also on suitability, side effects, cost and which regime suits you best. Tablets must be taken regularly according to the manufacturer’s instructions. Delayed illnesses - the incubation period of benign (mild) malaria may be long (up to a year or more).
If you experience any flu-like symptoms after returning you should seek immediate medical attention and tell the doctor about your background and recent travel history. (Particularly within 3 months of return but even up to 1 year and say you have been to a malarious area.)
You may need to take a supply of personal emergency treatment abroad with you if you are going to be remote from medical facilities since treatment should always be started promptly. Discuss this option with a Travel Advisor or other healthcare professional.
There may be alternative anti-malarial tablets that are suitable for your trip. Always check your destination(s) on Travel Health Pro to determine which malaria tablets are suitable for your trip. For advice on your travel destinations visit Central Travel Clinic.
Always read the patient information leaflet before commencing treatment.
View patient information leaflet.One tablet daily with food or a milky drink at about the same time each day.
Start taking the tablets 1-2 days before you enter the malaria area and continue until one week after you leave.
Malarone tablets are not recommended for malaria prophylaxis in persons under 40 kg bodyweight.
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Dr. Bryony Henderson is Medical Director for MedExpress UK, bringing extensive experience in clinical operations, governance and digital health. She has previously held roles dedicated to delivering safe, scalable care across well-known brands. She is a recognised clinical voice contributing to award-winning campaigns, publishing on health inequalities, and appearing across national media. Here, Bryony leads clinical governance and quality, supporting the delivery of safe, innovative and accessible healthcare.
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Adedayo Titiloye is Superintendent Pharmacist responsible for the safe and compliant delivery of pharmacy services across MedExpress. He brings experience across community pharmacy and regional operations, including leadership roles within one of the UK’s largest independent pharmacy groups. Here, Ade focuses on building high-performing teams, improving processes and ensuring pharmacy services deliver safe, effective care at scale.
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BSc (Hons), MSc, PhD
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Liyya Patel is Deputy Chief Pharmacist at MedExpress UK, with over 10 years’ experience supporting the organisation’s growth and development. She is responsible for ensuring pharmacy services are safe, compliant and meet all regulatory standards, playing a key role in maintaining high-quality clinical care. Liyya previously worked in high-volume community pharmacy settings in Central London and is a qualified pharmacist and independent prescriber.
Dr. Olivia de Rougemont
Dr. Olivia de Rougemont is a GP Lead at MedExpress with over 12 years’ experience across the NHS and private sectors. She has extensive experience in digital and in-person care, with a particular interest in women’s health, preventative medicine, and delivering patient-centred support that feels clear and accessible. Olivia also leads and mentors GPs, and brings a global perspective shaped by her experience working across different healthcare systems.