Switching treatments

There are several reasons why you and your prescriber may choose to switch from Mounjaro to Wegovy:

• Availability - ensuring you can continue treatment without interruption.
• Cost – Wegovy is often more cost-effective for long-term use.
• Tolerance – Switching may be advised if you’ve experienced difficult side effects on Mounjaro.
• Personal preference – some people simply prefer one medication’s delivery system or how it feels to take it.

Whatever the reason, our clinically-led team will create a personalised transition plan to help you maintain progress and minimise side effects.

This short video addresses the key differences between Wegovy and Mounjaro, as well as the benefits and considerations of each.

In most cases, yes. Both Mounjaro and Wegovy are GLP-1 receptor agonists, which is a type of medication that works in similar ways to regulate appetite and support weight loss. Because of this shared mechanism, switching between the two is generally well-tolerated when done under medical supervision.

Importantly, you don’t need to stop treatment for a “wash-out” period. If you’ve been tolerating Mounjaro well, you can take your final scheduled dose one week and begin Wegovy the next.

There’s no exact “one-to-one” match between Mounjaro and Wegovy doses, but we work out the closest safe equivalent for you to switch to. If you’ve been tolerating your current Mounjaro dose without significant side effects, your prescriber will consider starting you on the Wegovy dose that may provide a similar treatment effect. This sometimes involves a process called “off-label prescribing”.

Because both medications work in similar ways, your experience on Wegovy may feel familiar, especially if you tolerated Mounjaro well.

You may notice:

• Changes in appetite – some people find appetite suppression feels slightly different between the two medicines.
• Similar side effects – including mild nausea, constipation or diarrhoea, especially in the early weeks or after a dose increase.
• Weight loss patterns – the rate of weight loss may vary initially, but clinical research shows that by 12 months, Wegovy can deliver comparable results to Mounjaro for many people, especially when taken consistently.

Your prescriber will monitor your progress closely during the first months of treatment and adjust your plan if needed.

This short video addresses the key side effect differences between Wegovy and Mounjaro, and how to manage them.

Weight loss can take time, and that’s okay. In clinical studies, people using Wegovy (semaglutide 2.4mg) lost around 15% of their body weight after 68 weeks, while people using Mounjaro (tirzepatide 15mg) lost around 21% after 72 weeks.

Both treatments support significant and sustained results when used alongside healthy lifestyle changes.

A gradual approach helps support sustainable weight loss and can also reduce potential side effects.

• Stay consistent with your weekly injections. Avoid missing doses where possible.

• Keep track of any side effects and share these with your clinical team.

• Weight loss takes time. Steady progress is what’s recommended by clinicians.

• Maintain healthy routines around food, movement and sleep to support your treatment.

Every treatment plan is overseen by our medical team. We’ll review your history and current health, and assess how well you’ve tolerated any previous medication. Plus, we keep lifestyle front of mind, too.

Our clinicians will recommend a safe and effective dose and provide ongoing support through check-ins, advice and resources to help you adapt smoothly to your treatment plan.