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UK registered pharmacy
UK licensed treatments
Trusted by over 1.5 million people
Melatonin information
Melatonin is a natural hormone that our body releases after the onset of darkness. It makes people feel sleepy and it helps to regulate the body’s circadian rhythm.
Melatonin is licensed for the treatment of jet lag and it has been found to be particularly effective in those travelling eastwards.
It can also be used short-term in people aged 55 and over, who find it difficult to get to, or to stay, asleep.
Melatonin is a Prescription Only Medicine (POM) and cannot be bought over the counter.
Melatonin should not be taken by anybody with a hypersensitivity to any of the ingredients. It is not recommended for use in those with an autoimmune disease. Melatonin should be used with caution in people with renal or liver impairment and you should speak to your doctor before use as its use is not recommended. Melatonin interacts with various medicines and you should discuss with your doctor before use if you are taking other medications. Some of the medicines that can interact with Melatonin include fluvoxamine, contraceptive or hormone replacement therapy oestrogens, quinolones, carbamazepine, and rifampicin.
The usual dose is one 3mg tablet to be taken by mouth after food, 1 to 2 hours before bedtime. Tablets should be swallowed whole with a glass of water. Do not chew or crush.
It should not be taken before 8pm or after 4am in the time zone that you are in and should not be taken for more than 5 days in a row.
If one tablet is ineffective, the dose can be increased to a maximum of two 3mg tablets (6mg).
Side effects with melatonin are uncommon.
Melatonin can cause drowsiness, so it is important not to drive or operate machinery within 8 hours of taking it.
Recent studies have suggested melatonin may increase the risk of falls, accidents, memory disturbance, dependence and withdrawal symptoms and an increased risk of dementia.
In addition, melatonin can cause anxiety, fatigue, dry mouth, abdominal discomfort, a rise in blood pressure and mood changes.
Very rarely, melatonin has been associated with aggression, muscle complaints, seizures, urinary problems and vomiting.
Always read the label of any medication that you take and only take according to the instructions provided. Do not exceed the stated dose.
Always read the patient information leaflet before commencing treatment.
View patient information leaflet.85,000+ verified customer reviews
“Impressively quick service”
Impressively quick service. Easy site to navigate and meds delivered by reliable Royal Mail, so well pleased. Thank you!
“My full 5 star approval”
Great service, easy to navigate the questionnaire and far quicker service than waiting for the NHS services to approve and dispense your meds. Completely legitimate products, unlike so many other bogus sites. I have placed a couple of orders, even today, a Saturday, with estimated delivery this Monday. Awesome! This company has my full 5 star approval.
“Excellent service from the start”
Full information, quick delivery, follow up email. Professional would not purchase from anyone else.
“Very happy”
Fantastic service and very fast delivery, very happy with this service.
“Very fast delivery”
Very fast delivery, I am happy with the speed that I got to order what I needed and fast delivery, really needed to start taking the product. Thank you.
“Infinitely quicker”
Such an easy way to get medication quickly. Superb service and quick delivery. I couldn't even get through to my Drs so although this costs a bit more it's infinitely quicker.
“No hassle”
Fantastic and quick response, no hassle trying to get a doctor appointment, thanks MedExpress.
“I highly recommend them”
I have used them many times & the procedure is very easy & the delivery very quick.
“This is a brilliant service”
This is a brilliant service and so quick and efficient. I would have had to wait god knows how long for a GP appointment for this medication.
“Aftercare very good”
Checked properly by a doctor before medication was prescribed and aftercare very good. Received yesterday kept up to date with the delivery and had to sign for which I like so there's no missing parcel. Highly recommended.
“I would recommend!”
Trustworthy, professional and speedy delivery service. I have used this pharmacy a few times and I would recommend!
How it works
Step 2
Choose your treatment
Our qualified clinicians review your information and recommend treatment if it’s right for you.
Step 3
Get your treatment delivered
If prescribed, your treatment will arrive directly to you in discreet packaging.
Delivery options
Royal Mail 1st Class£2.90
Usually delivered the next working day
Special Delivery 1pm£5.95
Guaranteed next working day by 1pm
Special Delivery 9am£13.95
Guaranteed next working day by 9am
Post Office Collection£3.95
Usually collection next working day
Backed by our experienced UK-based medical team
Dr. Bryony Henderson
Dr. Bryony Henderson is Medical Director for MedExpress UK, bringing extensive experience in clinical operations, governance and digital health. She has previously held roles dedicated to delivering safe, scalable care across well-known brands. She is a recognised clinical voice contributing to award-winning campaigns, publishing on health inequalities, and appearing across national media. Here, Bryony leads clinical governance and quality, supporting the delivery of safe, innovative and accessible healthcare.
Adedayo Titiloye
Adedayo Titiloye is Superintendent Pharmacist responsible for the safe and compliant delivery of pharmacy services across MedExpress. He brings experience across community pharmacy and regional operations, including leadership roles within one of the UK’s largest independent pharmacy groups. Here, Ade focuses on building high-performing teams, improving processes and ensuring pharmacy services deliver safe, effective care at scale.
Dr. Carla Rodrigues
Dr. Carla Rodrigues is Head of Medical Operations at MedExpress, having previously held leadership roles in primary care networks and across well-known healthcare organisations, and has led scientific society groups in the field of sexual medicine. She has also completed training with MIT, Harvard and INSEAD. At HeliosX, Carla leads medical operations in the UK, overseeing the delivery of safe care pathways and upholding high standards in prescribing and clinical governance.
Dr. Kavir Matharu
Dr. Kavir Matharu is a GP Lead at MedExpress, with 10 years’ experience across a range of healthcare settings. She is a practising GP with a background in complex healthcare consulting, having worked on high-level strategic and operational challenges within the health system. She was also selected for a leadership fellowship with the National Medical Director at NHS England. Kavir has a strong interest in healthcare leadership and system improvement, with a focus on high-quality, sustainable care.
Dr. Daryl Perera
Dr. Daryl Perera is a GP Lead at MedExpress, with experience across NHS primary care, urgent care and private practice. He has extensive experience in digital healthcare and clinical leadership, and oversees clinical governance and patient safety across our digital health services. His work spans urgent care and preventative medicine, with particular interests in men’s health, obesity management, and sport and exercise medicine. Daryl has worked across a range of NHS and private healthcare organisations and previously held a GP Director role.
Dr. Sophie Dix
Head of Medical Affairs
BSc (Hons), MSc, PhD
Dr. Sophie Dix is Head of Medical Affairs at MedExpress and a behavioural neuroscientist with over 25 years’ experience across the pharmaceutical industry, charity sector and health technology. Her work has focused on understanding how to manage and treat conditions affecting both mind and body, bringing together scientific insight with real-world care. Sophie is passionate about evidence and ensuring people have access to the right treatment at the right time.
Dr. Zoe Lees
Medical Writer
BSc (Hons), MSc, PhD
Dr. Zoe Lees is a Medical Writer at MedExpress, specialising in clear, evidence-based health communications. She completed her postgraduate research at the University of Glasgow, focusing on metabolic complications of pregnancy and the role of adipose tissue function. Zoe brings a strong scientific foundation to her work and is committed to delivering content that is both accurate and accessible, grounded in robust research.
Dr. Adam Abbs
Dr. Adam Abbs is Medical Director, International at MedExpress responsible for expanding the company into new markets. He has extensive experience in asynchronous and video consultations, technology-enabled remote examinations and home biomarker testing, with a particular interest in educating both patients and doctors. Adam is a published author and is licensed to practice medicine in the UK and across the EU, and is registered in Canada.
Liyya Patel
Liyya Patel is Deputy Chief Pharmacist at MedExpress UK, with over 10 years’ experience supporting the organisation’s growth and development. She is responsible for ensuring pharmacy services are safe, compliant and meet all regulatory standards, playing a key role in maintaining high-quality clinical care. Liyya previously worked in high-volume community pharmacy settings in Central London and is a qualified pharmacist and independent prescriber.
Dr. Olivia de Rougemont
Dr. Olivia de Rougemont is a GP Lead at MedExpress with over 12 years’ experience across the NHS and private sectors. She has extensive experience in digital and in-person care, with a particular interest in women’s health, preventative medicine, and delivering patient-centred support that feels clear and accessible. Olivia also leads and mentors GPs, and brings a global perspective shaped by her experience working across different healthcare systems.