UK registered pharmacy
UK licensed treatments
Trusted by over 1.5 million people
Melatonin is a natural hormone that our body releases after the onset of darkness. It makes people feel sleepy and it helps to regulate the body’s circadian rhythm.
Melatonin is licensed for the treatment of jet lag and it has been found to be particularly effective in those travelling eastwards.
It can also be used short-term in people aged 55 and over, who find it difficult to get to, or to stay, asleep.
Melatonin is a Prescription Only Medicine (POM) and cannot be bought over the counter.
Melatonin should not be taken by anybody with a hypersensitivity to any of the ingredients. It is not recommended for use in those with an autoimmune disease. Melatonin should be used with caution in people with renal or liver impairment and you should speak to your doctor before use as its use is not recommended. Melatonin interacts with various medicines and you should discuss with your doctor before use if you are taking other medications. Some of the medicines that can interact with Melatonin include fluvoxamine, contraceptive or hormone replacement therapy oestrogens, quinolones, carbamazepine, and rifampicin.
The usual dose is one 3mg tablet to be taken by mouth after food, 1 to 2 hours before bedtime. Tablets should be swallowed whole with a glass of water. Do not chew or crush.
It should not be taken before 8pm or after 4am in the time zone that you are in and should not be taken for more than 5 days in a row.
If one tablet is ineffective, the dose can be increased to a maximum of two 3mg tablets (6mg).
Side effects with melatonin are uncommon.
Melatonin can cause drowsiness, so it is important not to drive or operate machinery within 8 hours of taking it.
Recent studies have suggested melatonin may increase the risk of falls, accidents, memory disturbance, dependence and withdrawal symptoms and an increased risk of dementia.
In addition, melatonin can cause anxiety, fatigue, dry mouth, abdominal discomfort, a rise in blood pressure and mood changes.
Very rarely, melatonin has been associated with aggression, muscle complaints, seizures, urinary problems and vomiting.
Always read the label of any medication that you take and only take according to the instructions provided. Do not exceed the stated dose.
Always read the patient information leaflet before commencing treatment.
View patient information leaflet.Impressively quick service. Easy site to navigate and meds delivered by reliable Royal Mail, so well pleased. Thank you!
Great service, easy to navigate the questionnaire and far quicker service than waiting for the NHS services to approve and dispens...
Full information, quick delivery, follow up email. Professional would not purchase from anyone else.
Fantastic service and very fast delivery, very happy with this service.
Great prices and service. Delivered on time, every time. 10/10.
Very fast delivery, I am happy with the speed that I got to order what I needed and fast delivery, really needed to start taking t...
Such an easy way to get medication quickly. Superb service and quick delivery. I couldn’t even get through to my Drs so although t...
Extremely professional, competitively priced, quick delivery
Fantastic and quick response, no hassle trying to get a doctor appointment, thanks MedExpress.
I have used them many times & the procedure is very easy & the delivery very quick.
This is a brilliant service and so quick and efficient. I would have had to wait god knows how long for a GP appointment for this ...
Checked properly by a doctor before medication was prescribed and aftercare very good. Received yesterday kept up to date with the...
Very quick to dispatch and customer service excellent
Trustworthy, professional and speedy delivery service. I have used this pharmacy a few times and I would recommend!
Good prices, communication and speed of delivery.

No GP or pharmacy visits, just a quick online consultation.
No GP or pharmacy visits, just a quick online consultation. Share your symptoms and a brief medical history in around two minutes, all from the comfort of your home.

Select from our recommended UK-licensed medications.
Select from our recommended UK-licensed medications. You don’t need an existing prescription.

We’ll deliver direct to you.
We’ll deliver direct to you. We always use discreet logo-free packaging, so only you know what’s inside. After it arrives, get ongoing support from our team.
Usually delivered the next working day
Guaranteed next working day by 1pm
Guaranteed next working day by 9am
Usually collection next working day