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Colofac contains mebeverine, an antispasmodic medicine, that relieves IBS symptoms. It relaxes muscle in your stomach and bowel to soothe cramps and spasms.
Take one tablet three times daily, ideally 20 minutes before meals. The medication will start to work after 1-2 hours.
Colofac starts to work after 1-2 hours.
Irritable bowel syndrome (IBS) is the name given to a collection of symptoms that affect your bowel. It’s thought to affect 10–20% of the population, particularly 20–30 year olds. Symptoms include:
You may find that eating makes your symptoms worse.
IBS has many causes. Research shows that food poisoning or gastroenteritis are common initial causes. Some IBS symptoms can overlap with other conditions, so it’s important to consult your doctor about any symptoms you’re experiencing. Always get a diagnosis from a healthcare professional before beginning any treatment.
Antispasmodic medications such as Colpermin, Alverine Citrate, peppermint oil, and Buscopan, can be effective at relieving symptoms.
You may find that IBS also responds to lifestyle changes, including:
Antispasmodic medications work by relaxing the smooth muscles in your gut. This reduces spasms, which are often the cause of the discomfort associated with IBS. They target gut muscles, providing fast relief from symptoms such as abdominal pain, cramps and bloating.
Side effects with antispasmodic medication are uncommon. In some cases, people have reported experiencing:
If you feel drowsy, dizzy, or experience any vision changes, you should avoid driving and operating machinery until these symptoms subside.
You shouldn’t take antispasmodic medication if you’re pregnant, breastfeeding or allergic to it.
Always read the patient information leaflet before starting treatment.
View patient information leafletImpressively quick service. Easy site to navigate and meds delivered by reliable Royal Mail, so well pleased. Thank you!
Great service, easy to navigate the questionnaire and far quicker service than waiting for the NHS services to approve and dispense your meds. Completely legitimate products, unlike so many other bogus sites. I have placed a couple of orders, even today, a Saturday, with estimated delivery this Monday. Awesome! This company has my full 5 star approval.
Full information, quick delivery, follow up email. Professional would not purchase from anyone else.
Fantastic service and very fast delivery, very happy with this service.
Very fast delivery, I am happy with the speed that I got to order what I needed and fast delivery, really needed to start taking the product. Thank you.
Such an easy way to get medication quickly. Superb service and quick delivery. I couldn’t even get through to my Drs so although this costs a bit more it’s infinitely quicker.
Fantastic and quick response, no hassle trying to get a doctor appointment, thanks MedExpress.
I have used them many times & the procedure is very easy & the delivery very quick.
This is a brilliant service and so quick and efficient. I would have had to wait god knows how long for a GP appointment for this medication.
Checked properly by a doctor before medication was prescribed and aftercare very good. Received yesterday kept up to date with the delivery and had to sign for which I like so there’s no missing parcel. Highly recommended.
Trustworthy, professional and speedy delivery service. I have used this pharmacy a few times and I would recommend!

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Dr. Bryony Henderson joins HeliosX as Medical Director for the UK and US, bringing extensive clinical operations, governance, and digital health experience from Kry/Livi and Numan. A recognised clinical voice, she has contributed to award-winning campaigns, published on health inequalities, and appeared across major national media. At HeliosX, she leads clinical governance and quality and supports the delivery of safe, innovative, scalable care.

Adam is a doctor and advocate for increasing access to healthcare internationally. He has extensive experience in video consultations, technology-enabled examinations, remote biomarker testing, and education. He is a published author and has medical licenses in the UK, Spain and Republic of Ireland.

Consultant GP and Quality Lead
MBBS, BSc, MRCGP, DRCOG, PGDip Clinical Dermatology
Safia is a GP with experience working in the NHS with a particular interest in diabetes and weight loss management. She is passionate about the power of digital healthcare and oversees our approach to patient safety and regulatory compliance.

Declan is a pharmacist with 15 years of experience and is passionate about digital healthcare. He has extensive experience across all pharmacy sectors in the UK and Ireland. He has led the clinical and regulatory functions of some of the biggest pharmacy organisations in the UK and is excited about the future of the industry.