Isotretinoin Gel 0.05% (Isotrex)

Acne Treatment

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Our Prices

Isotretinoin Gel 0.05% (Isotrex)

  • 1 x 30g - £24.99
  • 2 x 30g - £49.99
  • 3 x 30g - £74.99

Isotrex Information

What is Isotrex?

Isotrex Gel is a prescription only acne treatment. Isotrex Gel contains the active ingredient isotretinoin. Isotretinoin is similar to Vitamin A. It works by helping the skin so that blocked pores are less likely. This helps to prevent spots.

Isotrex Gel is used to treat acne (spots) in young people who are going through or have gone through puberty, and in adults. It is not for use by children who have not started puberty. Isotrex helps to:

  • loosen blackheads and whiteheads so that they come out more easily
  • stop new blackheads, whiteheads and spots from forming
  • lower the number of red, swollen acne spots.

What is the difference between tretinoin and isotretinoin?

Isotretinoin is very similar to the active ingredient tretinoin. It is known as an isomer which means that the chemical structure is very similar. Clinical studies have shown that isotretinoin is as effective as tretinoin for treating acne but for some individuals has less side effects.

How to Use Isotrex Gel

  1. Wash your hands.
  2. Completely remove any make-up.
  3. Wash the area with a mild soap and warm water, and dry gently.
  4. Put a thin layer of gel on the affected skin, using your fingertips, and smooth in.
  5. Apply to all of the area of your skin which has acne, not just each spot.
  6. Wash your hands after using the gel.

Side Effects

Side Effects

These effects can occur on the area of skin where you use the gel. If they cause you a problem, try using Isotrex less often, or stop using it for a few days until the irritation goes away, then start again. Stop using Isotrex if the irritation does not go away:
  • redness or peeling of your skin, especially during the first few weeks of use
  • slight stinging or skin pain
  • skin irritation or tenderness
  • skin burning sensation
  • dry skin
  • itching

Information Leaflet

Patient Information Leaflet

Always read the patient information leaflet before commencing treatment.

Authored 22 April 2014 by Dr Clare Morrison Reviewed 31 January 2019 by Liyya Patel, Siobhan Titre Last updated 11 November 2018

Recent Isotretinoin Reviews

5 / 5

Based on 3 independent customer reviews taken by Feefo (see all MedExpress Reviews).

"Great service"
By Lea on 09 August 2017


Exactly what I was after. Very happy


Ordering was problem free whilst being thorough enough to know you you were in safe hands. Delivery was excellent, I'm sure I received my order within 24hrs. Will be ordering again 100%

"Excellent service from start to receipt of medication."
By MedExpress Customer on 18 August 2017


Nothing has ever reduced the angry inflamed spots/ cysts like this product, excellent.


Excellent service, good consultation- process of prescription quick and able to view the process, very quick delivery and great communication of the tracking of parcel, highly recommend.

"Fast delivery"
By MedExpress Customer on 02 July 2017


Works. Nothing else does.


Fast delivery. Would prefer if they had paypal but otherwise great.

Read More Isotretinoin Reviews

Discreet Service

Plain packaging

Option to collect from
your local Post Office™

local branches

How our service works

It’s quick, easy, and safe to order from MedExpress — your fully regulated, London, United Kingdom based online pharmacy.

Free online

Start a free 2 minutes online consultation with simple questions about your health.


Our UK medical team will then recommend a treatment and issue a free prescription.


Your treatment will be sent direct from our London pharmacy in discreet packaging.

Watch our video to find out more

Our qualified team

All our doctors and pharmacists are based in the UK and are registered with the General Medical Council and General Pharmaceutical Council.

Dr Clare Morrison

General Practitioner (Prescriber)
GMC: 3441561

Avnish Patel

GPhC: 2079950

Liyya Patel

Superintendent Pharmacist
GPhC: 2083287

Choosing Generic vs Branded Isotretinoin


Generic medicines contain the same active ingredient and are equally effective and equivalent as the branded products but are available at a lower price. Generic manufacturers have to demonstrate that they are medically identical to the branded product before they can be sold - i.e. they offer the same quality, strength, stability and effectiveness.